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brain sketch

Brain Care 101

By:
Cheryl Myers

Just about everyone in the US has experienced what it is like to alter brain function. Maybe you had a cup of coffee and were suddenly more conversational, or a margarita and you were suddenly more conversational. Maybe you were partially anesthetized for a dental procedure and have hilarious videos to prove it.

These experiences show us we are not who we think we are. We are, at least partially, how our brain is currently functioning.

Our thoughts are influenced by a complex electrochemical soup that triggers emotions and actions. Our memories are physically coded into special areas of our brain. Our ability to walk, run, jump, and dance are coded into another area.

If the brain is not healthy, its poor functioning will manifest in thought and behavior changes. If we break a leg, no one is surprised that our walking ability is changed. But if the brain is not working correctly, and we exhibit sadness or lethargy or anxiety or some other unpleasant emotional state, we are often told to cheer up or settle down or get a grip. No one tells a boy with a broken leg to just get up and walk, darn it! Because brain functioning is not as visible, and because we are wedded to the idea that all behavior is—or should be—under our conscious control, people with these types of challenges are often stigmatized.

Therefore, it makes sense to take good care of our brain if our goal is healthy thinking, good memory, emotional stability, and predictable behavior.

Inflammation and Brain Function

Inflammation can create all kinds of havoc in proper brain functioning. There are many dietary and lifestyle interventions that can reduce inflammation, including reducing sugar in the diet, increasing whole food consumption, and maintaining healthy levels of movement throughout the day. There are also clinically proven supplements that have been shown to reduce brain inflammation.

The best all-around natural inflammation-reducing botanical is curcumin. Curcumin is extracted from turmeric, but turmeric will not deliver enough curcumin for medicinal benefits in people with brain health concerns. Turmeric contains only 2% to 5% curcumin. Turmeric is an excellent food, but curcumin is the natural medicine.

Early studies on ordinary curcumin required as many as 24 capsules a day to attain any serum levels of key compounds. The best curcumin forms have enhanced absorption so that medicinal levels can be achieved with only 2 capsules a day.

One enhanced absorption curcumin is BCM-95, which uses turmeric essential oils rich in turmerones as the delivery system, and has four published studies on major depressive disorder (MDD). It has been found that people with depression and anxiety both have elevated levels of inflammation in the brain. Inflamed tissues create neurotransmitter imbalances and suppress the brain’s auto-repair activity, called neurogenesis.

In one human study, this curcumin was compared to the prescription drug fluoxetine (one brand name is Prozac) and found to be as effective as the drug without the major side effects. BCM-95 has also been shown to be especially useful in atypical depression, which is often resistant to drug therapy.

Other studies on curcumin have shown it is effective for both depression and anxiety, and may be quite useful in other brain disorders, such as Parkinson’s and Alzheimer’s disease. Initial animal research has demonstrated potential for this herb to help people with autism as well.

How to Rebuild Your Brain

The omega-3 fatty acids from fish—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) —are crucial for proper brain health. About 60% of the brain is fat, and nearly 20% of your cerebral cortex is specifically DHA! If you are low on omega 3s, your brain will suffer. Not only are EPA and DHA anti-inflammatory, DHA is used in the brain cells themselves as part of the cell membrane.

Increasing healthy levels of EPA and especially DHA has great promise for schizophrenia, stroke, traumatic brain injury, depression, anxiety, autism and spectrum disorders, and more.

Even people without a serious brain disease can derive brain benefits from DHA and EPA from fish. In a published meta-analysis reviewing a variety of studies on mild memory problems associated with aging, using these two omega-3 fatty acids demonstrated significant improvements in memory in otherwise healthy older adults.

Another review article looked specifically at studies on DHA and found impact in almost every measure of cardiovascular health. This is important, because the same risk factors for heart disease are risk factors for strokes and other types of brain problems.

There is no question that omega 3s are beneficial for a healthy brain. However, there are an enormous amount of omega-3 products on the market, including oils from fish, squid (calamari), and krill, as well as more cutting edge extracts without oil from salmon. Losing the oil as a delivery system means you don’t have to worry about triglyceride content and/or rancidity.

The brain is a physical organ that responds to physical interventions. Helping to improve brain function in turn improves brain activity, whether it be mood, memory, or risk of disease. Lifestyle changes and clinically validated supplements can be more beneficial that once imagined, and it is never too late to late to make a difference.

Sources:

“Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease” by Z.J. Liu et al, Front Pharmacol, 8/16

 “Curcumin and Cognition: a Randomised, Placebo-controlled, Double-blind Study of Community-dwelling Older Adults” by S.R. Rainey-Smith et al., Br J Nutr, 4/16

"Curcumin and Major Depression: A Randomised, Double-blind, Placebo-controlled Trial Investigating the Potential of Peripheral Biomarkers to Predict Treatment Response and Antidepressant Mechanisms of Change” by A.L. Lopresti et al., European Neuropsychopharmacology, 12/5/14

“Curcumin for the Treatment of Major Depression: A Randomised, Double-blind, Placebo-controlled Study” by A.L. Lopresti et al., J Affect Disord, 2014

“Docosahexaenoic Acid and Adult Memory: A Systematic Review and Meta-analysis” by K. Yurko-Mauro et al., PLoS One, 3/15

 “Docosahexaenoic acid (DHA): An Essential Nutrient and a Nutraceutical for Brain Health and Diseases” by G.Y. Sun et al., Prostaglandins Leukot Essent Fatty Acids, 3/10/17

“Efficacy of Curcumin, and a Saffron/Curcumin Combination for the Treatment of Major Depression: A Randomised, Double-blind, Placebo-controlled Study” by A.L. Lopresti and P.D. Drummond, Journal of Affective Disorders, 2017

“Efficacy and Safety of Curcumin in Major Depressive Disorder: a Randomized Controlled Trial” by J. Sanmukhani et al, Phytother Res, 2013

“Impact of DHA on Metabolic Diseases from Womb to Tomb” by I.A. Arnoldussen and A.J. Kiliaan, Mar Drugs, 12/18/14

“Neuroprotective Effect of Curcumin as Evinced by Abrogation of Rotenone-induced Motor Deficits, Oxidative and Mitochondrial Dysfunctions in Mouse Model of Parkinson’s disease” by D.K. Khatri and A.R. Juvekar, Pharmacol Biochem Behav, 11-12/16

“Neuroprotective Potential of Curcumin in Combination with Piperine Against 6-hydroxy Dopamine Induced Motor Deficit and Neurochemical Alterations in Rats” by S. Singh and P. Kumar, Inflammopharmacology, 2/17

“Neuropsychopharmacotherapeutic Efficacy of Curcumin in Experimental Paradigm of Autism Spectrum Disorders” by R. Bhandari and A. Kuhad, Life Sci, 11/15

“Six-month Randomized Placebo-controlled, Double-blind, Pilot Clinical Trial of Curcumin in Patients with Alzheimer’s Disease” by L. Baum et al., J Clin Psychopharmacol, 2/08